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FUNDAMENTAL BIOLOGY AND BIOMEDICAL APPLICATIONS
(Saminathan et al., 2022)
A New Mechanism for Lysosomal Calcium Entry (Zajac et al., 2024)
Using our DNA nanodevices, we discovered that TMEM165 is a pH-dependent calcium importer for the lysosome, serving as a novel mechanism for lysosomal calcium entry.
Zajac, M.; Mukherjee, S.; Anees, P.; Oettinger, D.; Henn, K.; Srikumar, J.; Zou, J.; Saminathan, A.; Krishnan, Y. A Mechanism of Lysosomal Calcium Entry. Science advances 2024, 10 (7). https://doi.org/10.1126/sciadv.adk2317
Tissue-Specific Targeting (Huang et al., 2023)
We showed that DNA nanodevices can be targeted to specific tissues present in
C. elegans
through receptor-ligand interactions.
Huang, L. S.; Anas, M.; Xu, J.; Zhou, B.; Toth, P. T.; Krishnan, Y.; Di, A.; Malik, A. B. Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury. eLife. https://elifesciences.org/articles/83842 (accessed 2024-09-03).
Understanding Tubular Lysosomes (Suresh et al., 2021)
We measured pH and calcium gradients across tubular lysosomes and characterized tubular lysosomes' ability to promote phagocytosis.
Suresh, B.; Saminathan, A.; Chakraborty, K.; Zajac, M.; Cui, C.; Becker, L.; Krishnan, Y. Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis. PNAS 2021, 118 (41), e2113174118. https://doi.org/10.1073/pnas.2113174118.
Characterizing NOS3 Activity (Jani et al., 2020)
We used a DNA nanodevice, NOckout, to characterize the activity of NOS3 and how it relates to Golgi structural integrity.
Jani, M.S., Zou, J., Veetil, A.T. et al. A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution. Nat Chem Biol 16, 660–666 (2020). https://doi.org/10.1038/s41589-020-0491-3
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