Quantitative, Flourescent Chemical Sensors| University of Chicago

(Saminathan et al., 2022)

Targeting Tumor-Associated Macrophages (Cui et al., 2021)

We generated a lysosome-targeted DNA nanodevice in tumor-associated macrophages (TAMs) that has the ability to promote T cell activation.

Cui, C.; Chakraborty, K.; Xu Anna Tang; Schoenfelt, K. Q.; Hoffman, A.; Blank, A.; McBeth, B.; Pulliam, N.; Reardon, C. A.; Kulkarni, S. A.; Vaisar, T.; Ballabio, A.; Krishnan, Y.; Becker, L. A Lysosome-Targeted DNA Nanodevice Selectively Targets Macrophages to Attenuate Tumours. Nature Nanotechnology 2021, 16 (12), 1394–1402. https://doi.org/10.1038/s41565-021-00988-z.

Tissue-Specific Targeting (Chakraborty et al., 2021)

We showed that DNA nanodevices can be targeted to specific tissues present in C. elegans through receptor-ligand interactions.

Chakraborty, K.; Anees, P.; Surana, S.; Martin, S.; Aburas, J.; Moutel, S.; Perez, F.; Koushika, S. P.; Kratsios, P.; Krishnan, Y. Tissue-specific targeting of DNA nanodevices in a multicellular living organism. eLife. https://elifesciences.org/articles/67830#content (accessed 2024-09-03).

Measuring Voltage Across Cellular Pathways (Saminathan et al., 2021)

We generated a voltage-sensitive DNA nanodevice that is capable of mapping membrane potential across the endocytic, recycling, and retrograde trafficking pathway.

Saminathan, A.; Devany, J.; Veetil, A. T.; Suresh, B.; Pillai, K. S.; Schwake, M.; Krishnan, Y. A DNA-Based Voltmeter for Organelles. Nature Nanotechnology 2020, 16 (1), 96–103. https://doi.org/10.1038/s41565-020-00784-1.‌

CELL-SPECIFIC AND ORGANELLE-SPECIFIC TARGETING

Targeting Tumor-Associated Macrophages (Cui et al., 2021)

Tissue-Specific Targeting (Chakraborty et al., 2021)

Measuring Voltage Across Cellular Pathways (Saminathan et al., 2021)