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Quantitative, fluorescent chemical sensors
(Anees et al., 2024)
(Thekkan et al., 2019)
(Zou et al., 2024)
(Modi et al., 2009)
(Saha et al., 2015)
(Saminathan et al., 2021)
Measuring Organellar Potassium (Anees et al., 2023)
We generated a pH-correctable DNA nanodevice that can map potassium in the trans-Golgi network, early endosomes, and recycling endosomes.
Anees, P.; Saminathan, A.; Rozmus, E. R.; Di, A.; Malik, A. B.; Delisle, B. P.; Krishnan, Y. Detecting Organelle-Specific Activity of Potassium Channels with a DNA Nanodevice. Nature Biotechnology 2023. https://doi.org/10.1038/s41587-023-01928-z.
Measuring Organellar Sodium (Zou et al., 2023)
We generated a pH-independent probe to measure lumenal sodium levels in each stage of the endosomal pathway of mammalian cells and
C. elegans
cells.
Zou, J.; Mitra, K.; Anees, P.; Oettinger, D.; Ramirez, J. R.; Veetil, A. T.; Gupta, P. D.; Rao, R.; Smith, J. J.; Kratsios, P.; Krishnan, Y. A DNA Nanodevice for Mapping Sodium at Single-Organelle Resolution. Nature Biotechnology 2023, 1–9. https://doi.org/10.1038/s41587-023-01950-1.
Measuring HOCl Production in the Phagosome (Thekkan et al., 2019)
We generated a DNA-based combination reporter that can map both hypochlorous acid (HOCl) and pH simultaneously in the maturing phagosome.
Thekkan, S.; Jani, M. S.; Cui, C.; Dan, K.; Zhou, G.; Becker, L.; Krishnan, Y. A DNA-Based Fluorescent Reporter Maps HOCl Production in the Maturing Phagosome. 2019, 15 (12), 1165–1172. https://doi.org/10.1038/s41589-018-0176-3.
Measuring Organellar Calcium (Narayanaswamy et al., 2019)
We generated a pH-correctable DNA-based reporter that is capable of measuring calcium in acidic compartments such as lysosomes.
Narayanaswamy, N.; Chakraborty, K.; Saminathan, A.; Zeichner, E.; Leung, K.; Devany, J.; Krishnan, Y. A PH-Correctable, DNA-Based Fluorescent Reporter for Organellar Calcium. Nature Methods 2018, 16 (1), 95–102. https://doi.org/10.1038/s41592-018-0232-7.
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