Aug 2010-Dec 2015
: PhD in Bioorganic Chemistry; Thesis title. “Design, synthesis and applications of small molecular probes in studying canonical and non-canonical DNA
structures”. Supervisor: Prof. T. Govindaraju, New Chemistry Unit, JNCASR, Bangalore, Karnataka, India
Aug 2008-Jun 2010
: M. Sc in Chemistry with First class, University of Hyderabad, Hyderabad, Telangana, India.
Aug 2005-Jun 2008
: B.Sc (MPC) with Distinction, Andhra Pradesh Residential Degree College (APRDC), Nagarjuna Sagar, Acharya Nagarjuna University, Guntur, Andhra
Secured All India 26th rank in National Eligibility Test (NET) and called for Syama Prasad Mukherjee (SPM) interview for Junior Research Fellowship (JRF) in June-2010 conducted jointly by the Council of Scientific and Industrial Research
(CSIR) and University Grants Commission (UGC).
Qualified for GATE (Graduate Aptitude Test in Engineering) conducted by Indian Institute of Technology (IIT)-Guwahati in 2010 ( All India 165th Rank, percentile of 98.00 %).
Secured All India 10th rank in the entrance exam followed by personal interview, for admission into Master of Science in
Chemistry in 2008 conducted by University of Hyderabad (UoH), India.
Won the Gold Medal in 2008 for the highest marks achieved in Bachelor of Science from the Andhra Pradesh Residential Degree College
Design and synthesis of Red and NIR fluorescence probes for nucleic acids (dsDNA, RNA and G-quadruplex structures).
Stimuli responsive molecular probes for sensing and in vivo imaging applications in cells.
Small molecules conjugated DNA-nanodevices for metal ions sensing applications in cells.
Multi-step synthesis, solid-phase peptide synthesis, purification & spectral characterizations of organic molecules, cationic lipids, small peptides,
Red and NIR-fluorescence molecules in milligram to gram scales.
Hands-on experience in high resolution NMR (400 MHz), IR, UV-VIS spectrophotometer, LC-MS, GC-MS, HPLC (Normal Phase, RP-C4 and C18), automated flash
Multiple characterization techniques to confirm the small molecule-DNA interactions using various tools including UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, Atomic Force microscopy (AFM),
gel-electrophoresis (Agarose and PAGE) of DNA.
Culture and maintenance of various mammalian cell lines such as CHO, MCF-7, HeLa, U251, HacaT, HeLaDox, A549, MDA-MB 231 etc; MTT-based
cytotoxicity assays etc.
1. Narayanaswamy, N.; Nair, R. R.; Suseela, Y, V., Saini, D. K.; Govindaraju, T. Molecular Beacon-based DNA Switch for
Reversible pH sensing in Vesicles and Live Cells. Chem. Commun., 2016 (In press)
2. Narayanaswamy, N.; Narra, S.; Nair, R. R.; Saini, D. K.; Kondaiah, P.; Govindaraju, T. Stimuli-responsive colorimetric
and NIR fluorescence combination probe for selective reporting of cellular hydrogen peroxide. Chem. Sci., 2016, 7, 2832-2841.
3. Rajasekhar, K.; Naryanaswamy, N.; Murugan, N. A.; Kuang, G.; Ågren, H.; Govindaraju, T. A highly affinity red fluorescent and
colorimetric probe for Amyloid b aggregates. Sci. Rep., 2016, 6, 23668
4. Narayanaswamy, N.; Das, S.; Samanta, P. K.; Banu, K.; Sharma, G. P.; Mondal, N.; Dhar, S. K.; Pati, S. K.;
Govindaraju, T. Sequence-specific recognition of DNA minor groove by an NIR-fluorescence switch-on probe and its potential applications. Nucleic Acids Res., 2015, 43, 8651-8663.
5. Narayanaswamy, N.; Suresh, G.; Priyakumar, U. D.; Govindaraju. T. Double zipper helical assembly of
deoxyoligonucleotides: mutual templating and chiral imprinting to form hybrid DNA ensembles. Chem. Commun. 2015, 51, 5493-5496.
6. Narayanaswamy, N.; Unnikrishnan, M.; Gupta, M.; Govindaraju, T. Fluorescence reporting of G-quadruplex structures and
modulating their DNAzyme activity using polyethylenimine-pyrene conjugate. Bioorg. Med. Chem. Lett. 2015, 25, 2395-2400.
7. Narayanaswamy, N.; Kumar, M.; Das, S.; Sharma, R.; Samanta, P. K.; Pati, S. K.; Dhar, S. K.; Kundu, T. K.; Govindaraju. T. A thiazole
coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems. Sci. Rep. 2014, 4, 6476.
8. Narayanaswamy, N.; Avinash, M. B.; Govindaraju. T. Exploring hydrogen bonding and weak aromatic interactions induced
assembly of adenine and thymine functionalised naphthalenediimides. New J. Chem. 2013, 37,
International Symposium on Bioorganic Chemistry (ISBOC-10), IISER-Pune, January 11-15, 2015. Poster Title: “ Double zipper helical assembly of deoxyoligonucleotides: mutual templating and chiral imprinting to form hybrid DNA ensembles”.
Humboldt Kolleg, IISC-Bengalure, September 4th-6th, 2014. Poster Title: “A Thiazole coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems” ( Selected for oral presentation).
Indo-German Conference in Bioinspired Chemistry (IGCBIC-2014), IISC-Bengaluru, September 10th-12th, 2014.Poster Title: “ A Thiazole Coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems”.
International conference on chemical biology (ICCB-2014), IICT-Hyderabad, February 6th-8th, 2014. Poster Title: “Base pair specific DNA probe for nuclear staining and cell cycle analysis”.
Winter school-2014 on Frontiers in Materials Science, Jointly conducted by University Cambridge and JNCASR (ICMS)-Bengaluru, December 1st-5th, 2014. Poster Title: “ Double zipper helical assembly of deoxyoligonucleotides: mutual templating and chiral imprinting to form hybrid DNA ensembles”.
Ninth JNC research conference on Chemistry of Materials, Thiruvananthapuram-Kerala, October 14th-16th, 2013. Poster title: “Highly selective red fluorescent probe for base pair specific DNA recognition and nuclear staining” ( Selected for oral presentation).
Post-doctoral Scholar, Department of Chemistry, University of Chicago,
GCIS, E347A, 929, East 57th St, Chicago, IL 60637
Phone: +1 7737024364