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Kasturi Chakraborty

 

Current Research

    DNA nanodevices can provide functional readout on chemical cues affecting various pathways
    in cellulo and even in vivo.  My research involves studying the role of chloride in different sub- cellular compartments using a DNA scaffold based ratiometric chloride sensor.

Education

PhD. - (2013-present) - under the guidance of Prof. Yamuna Krishnan Department of Chemistry, University of Chicago.

MS, Chemistry – Organic Chemistry Specialization (2010-2012) University of Pune, Pune, Maharashtra, India

BS, Chemistry Honors (2007-2010).
St. Stephen's College, University of Delhi, New Delhi, India

Research Experience

National Chemical Laboratory (NCL), Pune, India. (2012)
6 month Research Project on synthesis of isomeric corniculatolides

National Centre for Biological Sciences (NCBS), Bangalore, India (2011)
2 month Research Project on study of a colorimetric sensor based on GNP aggregation mediated by A-motif formation.

IIT Kanpur, India (2009)
2 month Research Project on the study of encapsulation of proteins

Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India. (2008)

2 month Research Project on study and synthesis of various analogues of a peptide fragment
Aβ16-22 of Aβ protein whose aggregation is seen in Alzheimers.

Publications:

Narayanaswamy, N. #, Chakraborty, K. # *, Saminathan, A., Zeichner, E.H., Devany J. Leung, K. & Krishnan, Y*. A pH-correctable, DNA-based fluorescent reporter for organellar Calcium. Nature Methods. (Accepted).
# Equal contributions

Leung, K. #, Chakraborty, K.# & Krishnan, Y. A DNA Nanomachine chemically resolves lysosomes in live cells. Nat Nanotechnol (Accepted).
# Equal contributions

Devany, J., Chakraborty, K. & Krishnan, Y. Subcellular nanorheology reveals lysosomal viscosity as a reporter for lysosomal storage diseases. Nano Lett 18, 1351–1359 (2018).

Veetil, A. T., Chakraborty, K., Xiao, K., Minter , M.R., Sisodia, S.S. & Krishnan, Y. Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules. Nat Nanotechnol 12, 1183–1189 (2017).

Chakraborty, K., Leung, K. & Krishnan, Y. High lumenal chloride in the lysosome is critical for lysosome function. elife 6, e28862 (2017).

Chakraborty, K., Veetil, A. T., Jaffrey, S. R. & Krishnan, Y. Nucleic Acid-Based Nanodevices in Biological Imaging. Annu Rev Biochem 85, 349–373 (2016).

Prakash, V., Saha, S., Chakraborty, K. & Krishnan, Y. Rational design of a quantitative, pH-insensitive, nucleic acid based fluorescent chloride reporter. Chem. Sci. 7, 1946–1953 (2016).

Saha, S., Prakash, V., Halder, S., Chakraborty, K. & Krishnan, Y. A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells. Nat Nanotechnol 10, 645–651 (2015).

Raut, G. N., Chakraborty, K., Verma, P., Gokhale, R. S. & Srinivasa Reddy, D. Synthesis of isomeric corniculatolides. Tetrahedron Lett 53, 6343–6346 (2012).

Saha, S., Chakraborty, K. & Krishnan, Y. Tunable, colorimetric DNA-based pH sensors mediated by A-motif formation. Chem Commun (Camb) 48, 2513–2515 (2012).

Sundari, C., Chakraborty, K., Nagaraj, R. & Jagannadham, M. Characterization of Chemical Modification of Tryptophan by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. PPL 17, 168–171 (2010).

Research Scholar, Department of Chemistry, University of
Chicago, GCIS, E305A, 929,
East 57th St, Chicago, IL
60637.

Email:kasturi[at]uchicago.edu

kasturichakraborty[at]gmail.com


 

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