Nucleic acid-based Molecular Devices
Nucleic acid structure and dynamics
Nucleic acid structure and dynamicsStructural DNA nanotechnology is an emerging field that seeks to create exquisitely defined nanoscale architectures via the self-assembly of a set of carefully chosen DNA sequences.
Nucleic acid nano-devices in live imaging
Nucleic acid nano-devices in live imagingThe first demonstration of a DNA nanomachine functioning inside living systems came from our group. We showed that using I-switch, one could effectively map spatiotemporal pH changes associated with endosomal maturation both in living cells as well as within cells present in a living organism.
Naturally occurring nucleic acid nano-devices
Naturally occurring nucleic acid nano-devicesWe are also interested in understanding naturally occuring nucleic acid based devices such as non-coding RNAs. RNA is an exciting and powerful biological medium for making genetically encoded, synthetic nucleic acid architectures that can probe and program the cell.
2014 - Professor, University of Chicago
2014: Assoc Professor, National Centre for Biological Sciences (NCBS)
2009-13: Reader, NCBS, Bangalore
2005-9: Fellow, NCBS, Bangalore
2001-05: 1851 Research Fellowship, University of Cambridge, UK
2002: Ph. D., Indian Institute of Science (IISc), Bangalore,
1997: M.S., IISc, Bangalore,
1993: B. Sc. Madras University